Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Boceprevir and telaprevir may slow down how quickly your liver processes sildenafil and tadalafil.
What might happen:
Your blood levels of sildenafil or tadalafil may increase and cause harmful effects.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. If you are taking sildenafil or tadalafil for pulmonary arterial hypertension (PAH), contact your doctor right away. Contact your doctor if you experience a painful or prolonged erection, fainting or dizziness, or changes in vision. The dose of your sildenafil may need adjusting.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Victrelis (boceprevir) US prescribing information. Schering Corporation February, 2014.
2.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2013.