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iron fum-B6-B12-E-potassium

Interactions

Quinolones, Oral/Iron Salts, Oral (mono deleted 12/01/2011)

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, iron may prevent your body from absorbing your antibiotic properly.

What might happen:

The ability of your antibiotic to fight infection will decrease.

What you should do about this interaction:

You should time when you take your iron so that you do not take it: --for 6 hours before or 2 hours after ciprofloxacin. --for 3 hours before or 2 hours after gemifloxacin. --for 2 hours before or 2 hours after levofloxacin. --for 2 hours before or 2 hours after lomefloxacin. --within 8 hours before or 4 hours after moxifloxacin. --for 2 hours before or 2 hours after nalidixic acid. --for 2 hours before or 2 hours after norfloxacin. --for 2 hours before or 2 hours after ofloxacin. --for 2 hours before or 2 hours after trovafloxacin.If you are not sure which antibiotic you are on or if you have questions about the timing of doses of your medicine, contact your healthcare professionals (e.g. doctor or pharmacist). They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Cipro (ciprofloxacin hydrochloride) US prescribing information. Bayer Corporation February, 2011.

2.Factive (gemifloxacin mesylate) US prescribing information. Oscient Pharmaceuticals February, 2011.

3.Levaquin (levofloxacin) US prescribing information. Ortho-McNeil Pharmaceutical, Inc. February, 2011.

4.Maxaquin (lomefloxacin hydrochloride) US prescribing information. Pfizer Inc. March, 2004.

5.Avelox (moxifloxacin hydrochloride) US prescribing information. Bayer Pharmaceuticals Corporation February, 2011.

6.NegGram (nalidixic acid) US prescribing information. Sanofi-Synthelabo, Inc. November, 2012.

7.Noroxin (norfloxacin) US prescribing information. Merck & Co., Inc. September, 2011.

8.Floxin (ofloxacin) US prescribing information. Ortho-McNeil Pharmaceutical, Inc. February, 2011.

9.Polk RE, Healy DP, Sahai J, Drwal L, Racht E. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers. Antimicrob Agents Chemother 1989 Nov;33(11):1841-4.

10.LePennec MP, Kitzis MD, Terdjman M, Foubard S, Garbarz E, Hanania G. Possible interaction of ciprofloxacin with ferrous sulphate. J Antimicrob Chemother 1990 Jan;25(1):184-5.

11.Lomaestro BM, Bailie GR. Quinolone-cation interactions: a review. DICP 1991 Nov;25(11):1249-58.

12.Kara M, Hasinoff BB, McKay DW, Campbell NR. Clinical and chemical interactions between iron preparations and ciprofloxacin. Br J Clin Pharmacol 1991 Mar;31(3):257-61.

13.Campbell NR, Kara M, Hasinoff BB, Haddara WM, McKay DW. Norfloxacin interaction with antacids and minerals. Br J Clin Pharmacol 1992 Jan; 33(1):115-6.

14.Allen A, Bygate E, Faessel H, Isaac L, Lewis A. The effect of ferrous sulphate and sucralfate on the bioavailability of oral gemifloxacin in healthy volunteers. Int J Antimicrob Agents 2000 Aug;15(4):283-9.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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