How the interaction occurs:
When these two medicines are taken together, your body may not process your neuromuscular blocking medicine properly.
What might happen:
The effects of the neuromuscular blocking medicine may increase and cause toxic effects.
What you should do about this interaction:
Neuromuscular blockers are only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Bodley PO, Brett JE. Post-operative respiratory inadequacy and the part played by antibiotics. Anaesthesia 1962 Oct;17(4):438-443.
2.Emery ERJ. Neuromuscular blocking properties of antibiotics as a cause of post-operative apnoea. Anaesthesia 1963 Jan;18(1):57-65.
3.Foldes FF, Lunn JN, Benz HG. Prolonged respiratory depression caused by drug combinations. Muscle relaxants and intraperitoneal antibiotics as etiologic agents. J Am Med Assoc 1963 Feb 23;183(8):672-3.
4.Pinkerton HH, Munro JR. Respiratory insufficiency associated with the use of streptomycin. Scott Med J 1964;9:256-8.
5.Viljoen JF. Parenteral neomycin and muscle relaxants. Two case reports of interest. S Afr Med J 1966 Oct 29;40(39):963-4.
6.Warner WA, Sanders E. Neuromuscular blockade associated with gentamicin therapy. JAMA 1971 Feb 15;215(7):1153-4.
7.Levanen J, Nordman R. Complete respiratory paralysis caused by a large dose of streptomycin and its treatment with calcium chloride. Ann Clin Res 1975 Feb;7(1):47-9.
8.Geha DG, Blitt CD, Moon BJ. Prolonged neuromuscular blockade with pancuronium in the presence of acute renal failure: a case report. Anesth Analg 1976 May-Jun;55(3):343-5.
9.Waterman PM, Smith RB. Tobramycin-curare interaction. Anesth Analg 1977 Jul-Aug;56(4):587-8.
10.Sinha SK, Levene MI. Pancuronium bromide induced joint contractures in the newborn. Arch Dis Child 1984 Jan;59(1):73-5.
11.Burkett L, Bikhazi GB, Thomas KC Jr, Rosenthal DA, Wirta MG, Foldes FF. Mutual potentiation of the neuromuscular effects of antibiotics and relaxants. Anesth Analg 1979 Mar-Apr;58(2):107-15.
12.Pittinger C, Adamson R. Antibiotic blockade of neuromuscular function. Annu Rev Pharmacol 1972;12:169-84.
13.Fogdall RP, Miller RD. Prolongation of a pancuronium-induced neuromuscular blockade by clindamycin. Anesthesiology 1974 Oct; 41(4):407-8.