Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Tenecteplase helps break up clots in your body. Anticoagulants decrease your body's ability to make clots. When these two medicines are taken together, their effects may be increased.
What might happen:
You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, you may need to check your bleeding times more often. Do not start, stop, or change the dosage of any medicine before checking with them first. Let your doctor know right away if you have any symptoms of bleeding.
1.Metalyse (tenecteplase) Australian prescribing information. Boehringer Ingelheim Pty Ltd. September 5, 2003.
2.Metalyse (tenecteplase) UK summary of product characteristics. Boehringer Ingelheim Limited April 4, 2011.
3.TNKase (tenecteplase) Canada Product Monographh. Genentech, Inc. May 27, 2008.
4.TNKase (tenecteplase) US prescribing information. Genentech, Inc. May, 2011.