Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process the blood thinner more rapidly.
What might happen:
The beneficial effects of your blood thinner medicine may be decreased.
What you should do about this interaction:
If your doctor prescribes these medicines together, you may need to check your bleeding times more often. You may need an adjustment in the dose of your blood thinner.Make sure that your doctor knows all of the medicines that you are taking.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Cullen SI, Catalano PM. Griseofulvin-warfarin antagonism. JAMA 1967 Feb 20;199(8):582-3.
2.Johansson SA. Apparent resistance to oral anticoagulant therapy and influence of hypnotics on some coagulation factors. Acta Med Scand 1968 Oct;184(4):297-300.
3.Orme M, Breckenridge A, Brooks RV. Interactions of benzodiazepines with warfarin. Br Med J 1972 Sep 9;3(827):611-4.