Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Leucovorin enhances the effects of fluorouracil, including the side effects.
What might happen:
You may experience more severe and/or prolonged side effects, such as diarrhea, and mouth inflammation/sores.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Leucovorin calcium US prescribing information. Bedford Laboratories September, 2008.
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