Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nelfinavir may slow down how quickly your liver processes atorvastatin. Simeprevir may increase the amount of atorvastatin your body absorbs.
What might happen:
The amount of atorvastatin in your blood may increase and cause harmful effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any unexplained muscle pain, tenderness, weakness, or discoloration of your urine. Your doctor may want to change your cholesterol medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Lipitor (atorvastatin) US prescribing information. Pfizer Inc. October, 2012.
2.Viracept (nelfinavir mesylate) US prescribing information. Agouron Pharmaceuticals, Inc. March, 2015.
3.Hsyu PH, Schultz-Smith MD, Lillibridge JH, Lewis RH, Kerr BM. Pharmacokinetic interactions between nelfinavir and 3-hydroxy-3- methylglutaryl coenzyme A reductase inhibitors atorvastatin and simvastatin. Antimicrob Agents Chemother 2001 Dec;45(12):3445-50.
4.Olysio (simeprevir) US prescribing information. Janssen Products, LP April, 2015.