Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Amiodarone may slow down how quickly your liver processes your fentanyl.
What might happen:
The amount of fentanyl in your blood may increase and cause more side effects than expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to adjust the dose of your fentanyl or monitor its effects more closely.If you have unusually slow or shallow breathing, get help right away. If you feel more sleepy or tired than normal, contact your healthcare professional as soon as possible.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.
2.Duragesic (fentanyl) US prescribing information. Janssen Pharmaceuticals, Inc. August, 2014.
3.White CM, Dunn A, Tsikouris J, Waberski W, Felton K, Freeman-Bosco L, Giri S, Kluger J. An assessment of the safety of short-term amiodarone therapy in cardiac surgical patients with fentanyl-isoflurane anesthesia. Anesth Analg 1999 Sep;89(3):585-9.
4.Liberman BA, Teasdale SJ. Anaesthesia and amiodarone. Can Anaesth Soc J 1985 Nov;32(6):629-38.
5.Gallagher JD, Lieberman RW, Meranze J, Spielman SR, Ellison N. Amiodarone-induced complications during coronary artery surgery. Anesthesiology 1981 Aug;55(2):186-8.
6.MacKinnon G, Landymore R, Marble A. Should oral amiodarone be used for sustained ventricular tachycardia in patients requiring open-heart surgery?. Can J Surg 1983 Jul;26(4):355-7.
7.Navalgund AA, Alifimoff JK, Jakymec AJ, Bleyaert AL. Amiodarone-induced sinus arrest successfully treated with ephedrine and isoproterenol. Anesth Analg 1986 Apr;65(4):414-6.
8.Koblin DD, Romanoff ME, Martin DE, Hensley FA Jr, Larach DR, Stauffer RA, Luck JC Jr. Anesthetic management of the parturient receiving amiodarone. Anesthesiology 1987 Apr;66(4):551-3.
9.Meulendyk J. Anesthetic considerations with amiodarone: report of a case. J Am Osteopath Assoc 1984 Apr;83(8):585-8.