How the interaction occurs:
Rifampin and phenobarbital may speed up how quickly your liver processes your benzodiazepine.Phenobarbital and a benzodiazepine, especially when you first start them, may cause sedation or suppress your natural urge to breathe.
What might happen:
Over time, your benzodiazepine might not work as well.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have taken rifampin or phenobarbital in the previous two weeks. Let your doctor know if your medicine does not seem to be working as well, or if you might be having side effects such as sedation, confusion, feeling dizzy or uncoordinated. Your doctor may need to adjust the dose of your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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