Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Cinacalcet may slow down how quickly your liver processes desipramine.
What might happen:
The amount of desipramine in your blood may increase and result in an increase in sides effects like nausea and headache.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines. Let your doctor know if you have any symptoms nausea or headache.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Sensipar (cinacalcet hydrochloride) US prescribing information. Amgen Inc. August, 2011.
2.Harris RZ, Salfi M, Posvar E, Hoelscher D, Padhi D. Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl. Eur J Clin Pharmacol 2007 Feb;63(2):159-63.