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Norvir

Interactions

Ritonavir/Meperidine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process your pain medicine properly.

What might happen:

If you take these medicines together for a long time, or if your dose of meperidine is increased, you may have toxic effects from meperidine, such as drowsiness, slurred speech, or seizures.

What you should do about this interaction:

Talk to your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. If you need to be taking a narcotic pain medicine for a long time, or if your meperidine stops working as well and you need a larger dose, your doctor may want to change your pain medicine. Your healthcare professionals may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2012.

2.Piscitelli SC, Kress DR, Bertz RJ, Pau A, Davey R. The effect of ritonavir on the pharmacokinetics of meperidine and normeperidine. Pharmacotherapy 2000 May;20(5):549-53.

3.Demerol (meperidine hydrochloride) US prescribing information. Sanofi-Synthelabo, Inc. October, 2011.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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