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Antidiabetic, Oral/Chloramphenicol

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process the oral antidiabetic medicine properly.

What might happen:

The effects of your diabetes medicine may increase and you may experience symptoms from abnormally low blood sugar. These symptoms might include a a sudden onset of a cold sweat, dizziness, fatigue, shakiness, rapid heartbeat, nausea, vision changes, confusion, personality change, nervousness, and hunger.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible. Your doctor may want to adjust the dose of the diabetes medicine. If you experience any of the above mentioned symptoms, eat a quick source of sugar, such as table sugar, orange juice, honey, or non-diet soda. Tell your doctor about the reaction.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


1.Hansen JM, Kristensen M. Tolbutamde in the treatment of Parkinson's disease--a double blind trial. Dan Med Bull 1965 Dec;12(7):181-4.

2.Christensen LK, Skovsted L. Inhibition of drug metabolism by chloramphenicol. Lancet 1969 Dec 27;2(7635):1397-9.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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