How the interaction occurs:
When these two medicines are taken together, your body may not process the oral antidiabetic medicine properly.
What might happen:
The effects of your diabetes medicine may increase and you may experience symptoms from abnormally low blood sugar. These symptoms might include a a sudden onset of a cold sweat, dizziness, fatigue, shakiness, rapid heartbeat, nausea, vision changes, confusion, personality change, nervousness, and hunger.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible. Your doctor may want to adjust the dose of the diabetes medicine. If you experience any of the above mentioned symptoms, eat a quick source of sugar, such as table sugar, orange juice, honey, or non-diet soda. Tell your doctor about the reaction.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Hansen JM, Kristensen M. Tolbutamde in the treatment of Parkinson's disease--a double blind trial. Dan Med Bull 1965 Dec;12(7):181-4.
2.Christensen LK, Skovsted L. Inhibition of drug metabolism by chloramphenicol. Lancet 1969 Dec 27;2(7635):1397-9.