Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines can affect your pancreas.
What might happen:
You may develop a serious condition called pancreatitis. Pancreatitis can be life-threatening.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your HIV-regimen while you are taking pentamidine. If your doctor decides that taking these medicines together is the best regimen for you, you will be closely monitored for pancreatitis. Let your doctor know right away if you have any nausea, vomiting, or abdominal pain. Be sure to keep all laboratory appointments.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Hivid (zalcitabine) US prescribing information. Roche Pharmaceuticals September, 2002.