How the interaction occurs:
Probenecid may slow down the removal of NSAIDs from your body.
What might happen:
The level of the NSAID in your body may go increase and can increase your chance of having side effects from your medicine, such as blurred vision, drowsiness, or kidney problems.
What you should do about this interaction:
Inform your healthcare provider if you are taking any NSAIDs, such as indomethacin or naproxen. If you experience any side effects from your NSAID, inform your doctor immediately. Your doctor may want to change the dose of your medicine or for you to stop taking one of your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Brooks PM, Bell MA, Sturrock RD, Famaey JP, Dick WC. The clinical significance of indomethacin-probenecid interaction. Br J Pharmacol 1974; 1:287-90.
2.Skeith MD, Simkin PA, Healey LA. The renal excretion of indomethacin and its inhibition by probenecid. Clin Pharmacol Ther 1968 Jan-Feb;9(1):89-93.
3.Upton RA, Williams RL, Buskin JN, Jones RM. Effects of probenecid on ketoprofen kinetics. Clin Pharmacol Ther 1982 Jun;31(6):705-12.
4.Wollheim FA, Stenberg P, Nilsson B, Mellbin G. Clinical and methodological studies on intramuscular ketoprofen in postoperative rheumatic pain. Eur J Clin Pharmacol 1981;20(6):423-5.
5.Runkel R, Mroszczak E, Chaplin M, Sevelius H, Segre E. Naproxen-probenecid interaction. Clin Pharmacol Ther 1978 Dec;24(6):706-13.
6.Day RO, Geisslinger G, Paull P, Williams KM. Neither cimetidine nor probenecid affect the pharmacokinetics of tenoxicam in normal volunteers. Br J Clin Pharmacol 1994 Jan;37(1):79-81.