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Dainite-KI

Interactions

Apremilast; Roflumilast/CYP3A4 Inducers

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Carbamazepine, phenobarbital, phenytoin, and rifampin may speed up how quickly your liver processes apremilast and roflumilast.

What might happen:

Your apremilast or roflumilast may not work as well while you are taking these other medicines and for a few weeks after you stop taking them.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have them in the previous two weeks. Let your doctor know if your symptoms worsen. Your doctor may need to adjust your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Otezla (apremilast) US prescribing information. Celgene Corporation May, 2014.

2.Daxas (roflumilast) UK summary of product characteristics. Merck Sharp & Dohme Limited July, 2010.

3.Daliresp (roflumilast) US prescribing information. Forest Pharmaceutics, Inc. August, 2013.

4.Nassr N, Huennemeyer A, Herzog R, von Richter O, Hermann R, Koch M, Duffy K, Zech K, Lahu G. Effects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects. Br J Clin Pharmacol 2009 Oct;68(4):580-7.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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