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    altretamine

    COMMON BRAND NAME(S): Hexalen

    GENERIC NAME(S): ALTRETAMINE

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    WARNINGS:

    Altretamine may cause serious side effects (such as bleeding/blood problems, nerve problems). Bleeding/blood problems can cause anemia, lower your body's ability to fight an infection, or cause your body to bruise or bleed more easily. Your doctor will check you closely to lessen the chance of serious side effects. Tell your doctor right away if you develop symptoms such as easy bruising/bleeding, unusual tiredness, fast/pounding heartbeat, numbness/tingling of the arms/legs, mental/mood changes, seizures, loss of coordination, dizziness, signs of infection (such as sore throat that doesn't go away, fever, chills).

    Who should not take altretamine?
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    Uses

    This medication is used to treat cancer of the ovaries. It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

    How to use altretamine

    Take this medication by mouth as directed by your doctor, usually 4 times a day (after meals and at bedtime). It is usually taken for a 2 or 3-week period, then stopped for a time and repeated. This is called a treatment cycle. Carefully follow your doctor's directions for taking this drug. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

    The dosage is based on your body size and response to treatment. Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

    Side Effects

    See also Warning section.

    Nausea, vomiting, or loss of appetite may occur. Nausea and vomiting can be severe. In some cases, your doctor may reduce your dose or prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals or limiting activity may help lessen some of these effects. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Temporary hair loss may rarely occur. Normal hair growth should return after treatment has ended.

    Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine), signs of liver problems (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine).

    A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

    This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

    In the US -

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

    In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

    Precautions

    Before taking altretamine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

    Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding/blood problems, brain/nerve disorders, current/recent/returning infections, kidney disease, liver disease.

    Altretamine can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

    Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

    To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

    This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

    Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

    Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using altretamine. Altretamine may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

    It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

    Interactions

    Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

    Some products that may interact with this drug are: nalidixic acid, pyridoxine (vitamin B6), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine).

    Overdose

    If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

    Notes

    Do not share this medication with others.

    Lab and/or medical tests (such as complete blood count, neurologic exam) should be done while you are taking this medication. Keep all medical and lab appointments.

    Missed Dose

    If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

    Storage

    Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

    Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

    MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

    Information last revised July 2016. Copyright(c) 2016 First Databank, Inc.

    Images

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    HEXALEN 50 MG CAPSULE
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    HEXALEN 50 MG CAPSULE
    HEXALEN 50 MG CAPSULE

    Identification

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    This medicine is a clear, oblong capsule imprinted with "USB 001".

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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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