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edetate calcium disodium injection

Interactions

Digitalis Glycosides/Intravenous Calcium Products

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Giving calcium too quickly through the veins can increase the effects of your digitalis glycoside.

What might happen:

You may develop an irregular heartbeat.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Lanoxin (digoxin) Tablets US prescribing information. GlaxoSmithKline August, 2012.

2.Bower JO, Mengle HAK. The additive effect of calcium and digitalis. JAMA 1936 Apr 4;106(14):1151-53.

3.Nola GT, Pope S, Harrison DC. Assessment of the synergistic relationship between serum calcium and digitalis. Am Heart J 1970 Apr;79(4):499-507.

4.Hougen TJ, Smith TW. Inhibition of myocardial monovalent cation active transport by subtoxic doses of ouabain in the dog. Circ Res 1978 Jun; 42(6):856-63.

5.Brown RH Jr, Cohen I, Noble D. The interactions of protons, calcium and potassium ions on cardiac Purkinje fibres. J Physiol 1978 Sep;282:345-52.

6.Hansteen V, Jacobsen D, Knudsen K, Reikvam A, Skuterud B. Acute, massive poisoning with digitoxin: report of seven cases and discussion of treatment. Clin Toxicol 1981 Jun;18(6):679-92.

7.Brown DD, Juhl RP. Altered bioavailability of digoxin produced by gastrointestinal medications. Clin Res 1979;27:610A.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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