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Drugs & Medications

lomustine

COMMON BRAND NAME(S): Ceenu, Gleostine

GENERIC NAME(S): LOMUSTINE

WARNINGS:

Lomustine decreases bone marrow function, an effect that may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. These side effects usually occur 4 to 6 weeks after your dose. Tell your doctor right away if you develop any of the following symptoms: unusual tiredness, pale skin, signs of infection (such as sore throat that doesn't go away, fever, chills), easy bruising/bleeding.

Your doctor will closely monitor you and perform weekly blood tests for at least 6 weeks after each dose. Your dose and any further treatment will be based on your blood tests. You will have to wait at least 6 weeks between doses.

Who should not take lomustine?
See More

Uses

This medication is used to treat various types of cancer. Lomustine belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.

How to use lomustine

See also Warning section.

Take this medication by mouth as a single dose as directed by your doctor, usually once every 6 weeks. Your dose may consist of 2 or more different strengths/colors of capsules. To prevent nausea and vomiting, take this medication on an empty stomach at least 1 hour before or 2 to 3 hours after a meal with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Swallow the capsules whole.

The dosage is based on your medical condition, response to treatment, body size, and lab tests.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Wear rubber or latex gloves when you handle the capsules.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.

Side Effects

See also Warning section.

Nausea, vomiting, loss of appetite, diarrhea, or mouth/lip sores may occur. Nausea and vomiting usually last for less than 24 hours and loss of appetite may last for several days. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: confusion, swelling of lower legs/feet, vision changes.

Get medical help right away if you have any very serious side effects, including: stomach/abdominal pain that doesn't go away, black stools, vomit that looks like coffee grounds, yellowing eyes/skin, dark urine, signs of kidney problems (such as change in the amount of urine, pink urine).

A severe (sometimes fatal) lung problem (pulmonary fibrosis) has occurred in people taking this drug. This condition can occur months to years after you start taking this medication. Get medical help right away if you experience any of these serious side effects: cough, chest pain, difficult/painful breathing.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking lomustine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current infection, blood disorder (such as anemia, clotting problem), kidney disease, liver disease, lung disease.

Lomustine can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. It is important to prevent pregnancy while using this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms, birth control pills) while using this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, kidney/liver/lung tests) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to take each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.

Storage

Store in a tightly closed container at room temperature away from light and moisture. Avoid too much heat. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

GLEOSTINE 5 MG CAPSULE
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CEENU 10 MG CAPSULE
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CEENU 40 MG CAPSULE
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CEENU 100 MG CAPSULE
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CPL 3032, 100 mg
GLEOSTINE 5 MG CAPSULE

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color
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This medicine is a yellow, oblong capsule imprinted with "CPL 3033" and "5 mg".
CEENU 10 MG CAPSULE
CEENU 10 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "BRISTOL 3030" and "10 mg".
GLEOSTINE 10 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "CPL 3030" and "10 mg".
LOMUSTINE 10 MG CAPSULE
LOMUSTINE 10 MG CAPSULE

Identification

color
white
shape
oblong
imprint
BRISTOL 3030, 10 mg
This medicine is a white, oblong capsule imprinted with "BRISTOL 3030" and "10 mg".
CEENU 40 MG CAPSULE
CEENU 40 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "BRISTOL 3031" and "40 mg".
GLEOSTINE 40 MG CAPSULE
GLEOSTINE 40 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a white, oblong capsule imprinted with "CPL 3031" and "40 mg".
LOMUSTINE 40 MG CAPSULE
LOMUSTINE 40 MG CAPSULE

Identification

color
white
shape
oblong
imprint
CPL 3031, 40 mg
This medicine is a white, oblong capsule imprinted with "CPL 3031" and "40 mg".
CEENU 100 MG CAPSULE
CEENU 100 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a green, oblong capsule imprinted with "BRISTOL 3032" and "100 mg".
GLEOSTINE 100 MG CAPSULE
GLEOSTINE 100 MG CAPSULE

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a green, oblong capsule imprinted with "CPL 3032" and "100 mg".
LOMUSTINE 100 MG CAPSULE
LOMUSTINE 100 MG CAPSULE

Identification

color
green
shape
oblong
imprint
CPL 3032, 100 mg
This medicine is a green, oblong capsule imprinted with "CPL 3032" and "100 mg".

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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