How the interaction occurs:
Boceprevir, the combination of ombitasvir-paritaprevir-ritonavir, and telaprevir may slow down how quickly your body processes amlodipine.
What might happen:
The amount of amlodipine in your blood may increase and cause more side effects than normally expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Contact your doctor if you experience any chest discomfort, severe dizziness, fainting, or fast heartbeat.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Victrelis (boceprevir) US prescribing information. Schering Corporation July, 2014.
2.Viekira Pak (ombitasvir, paritaprevir, and ritonavir; dasabuvir) US prescribing information. AbbVie Inc. December, 2014.
3.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2013.
4.Lee JE, van Heeswijk R, Alves K, Smith F, Garg V. Effect of the hepatitis C virus protease inhibitor telaprevir on the pharmacokinetics of amlodipine and atorvastatin. Antimicrob Agents Chemother 2011 Oct; 55(10):4569-74.
5.FDA. CDER Application number: 2066190 Viekira Pak (ombitasvir, paritaprevir, ritonavir, dasabuvir) Clinical Pharmacology and Biopharmaceutics Review(s). URL: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206619Orig1s000Clin PharmR.pdf December 19, 2014.