How the interaction occurs:
Your antibiotic may slow down how quickly your liver processes quetiapine.
What might happen:
The amount of quetiapine in your blood may increase and cause more side effects.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your quetiapine while you are taking your antibiotic. Let your doctor know if you notice an increase in side effects from your medicine, especially excessive drowsiness, rapid pulse, weakness, fatigue, or dizziness.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.
2.Seroquel (quetiapine) US prescribing information. AstraZeneca Pharmaceuticals LP October, 2013.
3.Seroquel (quetiapine) Canada prescribing information. AstraZeneca Canada Inc. May 15,2013.
4.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2014..
5.Kasahara M, Suzuki H, Komiya I. Studies on the cytochrome P450 (CYP)-mediated metabolic properties of miocamycin: evaluation of the possibility of a metabolic intermediate complex formation with CYP, and identification of the human CYP isoforms. Drug Metab Dispos 2000 Apr; 28(4):409-17.
6.Li KY, Li X, Cheng ZN, Zhang BK, Peng WX, Li HD. Effect of erythromycin on metabolism of quetiapine in Chinese suffering from schizophrenia. Eur J Clin Pharmacol 2005 Jan;60(11):791-5.