Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nalbuphine may prevent your other pain medicine from working.
What might happen:
If you have taken opioid medicines for a while, buprenorphine, butorphanol, and nalbuphine may cause you to experience withdrawal symptoms.If you have only taken opioid medicines for a short time, and these medicines may reduce some of the side effects of your medicine, such as itching or shallow breathing; however, your opioid may not control your pain as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and how long you have been taking an opioid. If your pain gets worse, or if you have withdrawal symptoms such as trouble sleeping, sweating, widened pupils, runny nose, watering eyes, irritability, weakness, muscle aches/twitching/cramps, stomach cramps, hot/cold flashes, sneezing, vomiting, diarrhea, rapid breathing, fast heartbeat, and/or fever, contact your doctor.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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