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Vytorin 10-20

Interactions

Lovastatin; Simvastatin/Voriconazole

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Voriconazole may slow down how quickly your liver processes your cholesterol medicine.

What might happen:

The amount of cholesterol medicine in your blood may increase and cause muscle damage.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may tell you to stop taking your cholesterol medicine while you are taking voriconazole or change your cholesterol medicine. Let your doctor know right away if you have any unexplained muscle pain, tenderness, or weakness (especially with a fever or unusual tiredness).Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Mevacor (lovastatin) US prescribing information. Merck & Co., Inc. February, 2014.

2.Zocor (simvastatin) US prescribing information. Merck & Co., Inc. February, 2014.

3.Vfend (voriconazole) US prescribing information. Pfizer Inc. November, 2011.

4.Lipitor (atorvastatin) US prescribing information. Pfizer Inc. October, 2012.

5.Cool RM, Gulbis AM. Rhabdomyolysis after concomitant ese of simvastatin and voriconazole in an allogeneic stem cell transplant patient. J Pharm Technol May/June 2013;29(3):135-8.

6.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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