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Dynacin

Interactions

Digoxin, Oral/Tetracyclines

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process digoxin properly.

What might happen:

The blood levels of digoxin may increase and cause toxic effects.

What you should do about this interaction:

If you experience nausea, vomiting, diarrhea, loss of appetite, or very slow heartbeat, contact your doctor. The dose of your medicines may need adjusting. The effect of this interaction may last for several months after you finish taking your antibiotic.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Lindenbaum J, Tse-Eng D, Butler VP Jr, Rund DG. Urinary excretion of reduced metabolites of digoxin. Am J Med 1981 Jul;71(1):67-74.

2.Lindenbaum J, Rund DG, Butler VP Jr, Tse-Eng D, Saha JR. Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. N Engl J Med 1981 Oct 1;305(14):789-94.

3.Lanoxin (digoxin) Tablets US prescribing information. GlaxoSmithKline August, 2012.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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