Phosphate Supplements;Urine pH Modifiers/Phosphate Reducers Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Lanthanum, sevelamer, and tenapanor decrease the amount of phosphate your body absorbs. Phosphate supplements replace phosphate and some urinary pH modifiers are high in phosphate.

What might happen:

Your medicines may work against each other.

What you should do about this interaction:

Ask your healthcare professionals (e.g. doctor or pharmacist) before taking these drugs together.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Renagel (sevelamer hydrochloride) US prescribing information. Genzyme Corporation March 9, 2016.
  • 2.Fosrenol (lanthanum carbonate) US prescribing information. Shire US Inc. May, 2020.
  • 3.Xphozah (tenapanor) US prescribing information. Ardelyx, Inc. October 2023.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.