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Interactions

Darifenacin/Grapefruit Juice

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.

Medical warning:

Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.

How the interaction occurs:

Grapefruit juice may increase the amount of darifenacin in your blood.

What might happen:

When darifenacin is taken with grapefruit juice, the grapefruit juice may cause the darifenacin to build up in your body. This increased amount of darifenacin will have a greater effect of both desired and undesired effects. You may notice an increase in side effects, such as blurred vision, dizziness, drowsiness, dry mouth, upset stomach, headache, dry eyes, or constipation.

What you should do about this interaction:

If you notice an increase in any side effects from your medicine, contact your healthcare professional (e.g. doctor or pharmacist). Your doctor may want you to decrease the dose of your overactive bladder medicine while you are taking your other medicine.While you are taking this medicine, you should avoid eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage (such as orange juice). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice you should discuss with your doctor the effects of grapefruit on the blood levels of this medicine. These effects can occur even if grapefruit is not consumed at the same time of the darifenacin dose. This interaction may occur at any time in your treatment with darifenacin if grapefruit or grapefruit juice is consumed.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Enablex (darifenacin) US prescribing information. Warner Chilcott (US), LLC March, 2012.

2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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