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    M-R-Vax II subcutaneous


    Rubella Vaccine/Rho Immunoglobulin

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    Some types of immunoglobulins may prevent your immune system from properly responding to the rubella vaccine. However, if you receive the small dose the Rho immunoglobulin given after childbirth, these medicines may not interact.

    What might happen:

    There is a chance that the vaccine may not prevent rubella infection. The US Centers for Disease Control(CDC) states postpartum doses of Rho Immunoglobulin do not appear to interact with the Rubella vaccine. Never-the-less, the CDC recommends you have your blood checked 3 or more months after your rubella vaccination to be sure you are protected from a rubella infection.

    What you should do about this interaction:

    Let your healthcare professionals (e.g. doctor or pharmacist) know if you have received Rho immune globulin in the previous three months. A few months after your vaccination, your doctor may want to check your blood to make sure you have developed immunity. If you have not developed immunity, you will need a repeat dose of the rubella vaccine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


    1.WinRho SDF (anti-D (Rho) immunoglobulin (human)) Australian prescribing information. CSL August 30, 2002.

    2.Rhophylac (human immunoglobulin anti-D (Rh)) UK prescribing information. ZLB Bioplasma UK Limited December 19, 2003.

    3.Rhophylac (Rho human immune globlin) US prescribing information. ZLB Bioplasma Inc. January, 2004.

    4.Bayrho-D (immune globulin, Rho(D) human) Canadian prescribing information. Bayer 2004.

    5.WinRho SDF (Rho(D) immune globulin intravenous (human)) US prescribing information. Baxter Healthcare Corporation December, 2005.

    6.RhoGAM (Rho immune globulin human) US prescribing information. Ortho-Clinical Diagnostics, Inc. November, 2012.

    7.Centers for Disease Control and Prevention. General Recommendations on Immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR January 28, 2011;60(RR No.2):1-64.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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