How the interaction occurs:
Some types of immunoglobulins may prevent your immune system from properly responding to the rubella vaccine. However, if you receive the small dose the Rho immunoglobulin given after childbirth, these medicines may not interact.
What might happen:
There is a chance that the vaccine may not prevent rubella infection. The US Centers for Disease Control(CDC) states postpartum doses of Rho Immunoglobulin do not appear to interact with the Rubella vaccine. Never-the-less, the CDC recommends you have your blood checked 3 or more months after your rubella vaccination to be sure you are protected from a rubella infection.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know if you have received Rho immune globulin in the previous three months. A few months after your vaccination, your doctor may want to check your blood to make sure you have developed immunity. If you have not developed immunity, you will need a repeat dose of the rubella vaccine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.WinRho SDF (anti-D (Rho) immunoglobulin (human)) Australian prescribing information. CSL August 30, 2002.
2.Rhophylac (human immunoglobulin anti-D (Rh)) UK prescribing information. ZLB Bioplasma UK Limited December 19, 2003.
3.Rhophylac (Rho human immune globlin) US prescribing information. ZLB Bioplasma Inc. January, 2004.
4.Bayrho-D (immune globulin, Rho(D) human) Canadian prescribing information. Bayer 2004.
5.WinRho SDF (Rho(D) immune globulin intravenous (human)) US prescribing information. Baxter Healthcare Corporation December, 2005.
6.RhoGAM (Rho immune globulin human) US prescribing information. Ortho-Clinical Diagnostics, Inc. November, 2012.
7.Centers for Disease Control and Prevention. General Recommendations on Immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR January 28, 2011;60(RR No.2):1-64.