How the interaction occurs:
When sodium phosphate is used to cleanse the bowel (generally done before certain medical procedures such as a colonoscopy) and you are taking an NSAID, it may increase your risk of kidney damage.
What might happen:
You may develop a condition called acute phosphate nephropathy, which may decrease your kidney function. Symptoms include malaise, lethargy, drowsiness, decreased urine production, and swelling of the ankles, feet, and legs.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Prior to using sodium phosphate to prepare for your procedure, let your doctor know if you have a history of kidney problems; have used a laxative for constipation in the previous week; use diuretics, angiotensin converting enzyme (ACE) inhibitors or angiotensin converting enzyme (ARBs, medicines for blood pressure), or NSAIDs; or have active colitis or delayed bowel emptying. Drink lots of clear liquids before, during, and after your procedure. After your procedure, let your doctor know if you develop malaise, lethargy, drowsiness, decreased urine production, and swelling of the ankles, feet, and legs.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Anonymous. Food and Drug Administration Science Background Paper: Acute Phosphate Nephropathy and Renal Failure Associated With the Use of Oral Sodium Phosphate Bowel Cleansing Products. Available at: http://www.fda.gov/downloads/drugs/drugsafety/postmarketdrugsafetyinformat ionforpatientsandproviders/ucm161579.pdf Downloaded December 15, 2008..
2.Anonymous. Information for Healthcare Professionals: Oral Sodium Phosphate (OSP) Products for Bowel Cleansing (marketed as Visicol and OsmoPrep, and oral sodium phosphate products available without a prescription). Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPati entsandProviders/ucm126084.htm Accessed December 15, 2008..
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