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Actonel with Calcium

Interactions

Oral Bisphosphonates/Food Interaction

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.

Medical warning:

Most important. A change in your diet, medicine, or dosage is likely to be necessary. Promptly consult your doctor or pharmacist.

How the interaction occurs:

Food, coffee, and orange juice can prevent your body from absorbing your osteoporosis medicine.

What might happen:

The amount of osteoporosis medicine in your blood may decrease and it may not work as well.

What you should do about this interaction:

Take your osteoporosis medicine with water first thing upon arising for the day.If you are taking alendronate or risedronate, wait at least 30 minutes after taking your osteoporosis medicine before you eat anything, drink coffee or orange juice, or take other medicines.If you are taking clodronate or ibandronate, wait at least 60 minutes after taking your osteoporosis medicine before you eat anything, drink coffee or orange juice, or take other medicines.If you are taking etidronate or tiludronate, wait at least 2 hours after taking your osteoporosis medicine before you eat anything, drink coffee or orange juice, or take other medicines.Contact your healthcare professional (e.g., doctor or pharmacist) for more information.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.

References:

1.Fosamax (alendronate sodium) US prescribing information. Merck & Co., Inc. December, 2006.

2.Actonel (risedronate sodium) US prescribing information. Warner Chilcott (US), LLC April, 2013.

3.Loron (disodium clodronate) UK summary of product characteristics. Roche Products Limited October 25, 2006.

4.Boniva (ibandronate sodium) tablets US prescribing information. Roche Therapeutics, Inc. April, 2013.

5.Didronel (etidronate disodium) US prescribing information. Warner Chilcott (US), LLC April, 2013.

6.Skelid (tiludronate disodium) US prescribing information. Sanofi-Aventis U.S. LLC March, 2010.

7.Gertz BJ, Holland SD, Kline WF, Matuszewski BK, Freeman A, Quan H, Lasseter KC, Mucklow JC, Porras AG. Studies of the oral bioavailability of alendronate. Clin Pharmacol Ther 1995 Sep;58(3):288-98.

8.Gertz BJ, Holland SD, Kline WF, Matuszewski BK, Porras AG. Clinical pharmacology of alendronate sodium. Osteoporos Int 1993;3 Suppl 3:S13-6.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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