Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both tofacitinib and your other medicine affect how your immune system works.
What might happen:
Using these medicines together increases your risk of a life-threatening infection.
What you should do about this interaction:
Let sure your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Let your doctor know right away if you develop any fatigue, shortness of breath, chills, aches, fever, nausea, vomiting, weakness, or a painful rash/blisters.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Xeljanz (tofacitinib) US prescribing information. Pfizer Inc. November, 2012.