Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Erythromycin may slow down how quickly your body processes buspirone.
What might happen:
The amount of buspirone in your blood may increase and cause more side effects than normal, such as lightheadedness, dizziness, weakness, or sleepiness.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your buspirone while you are taking erythromycin.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Kivisto KT, Lamberg TS, Kantola T, Neuvonen PJ. Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole. Clin Pharmacol Ther 1997 Sep;62(3):348-54.
2.Buspar (buspirone hydrochloride) Australian prescribing information. Bristol-Myers Squibb Australia Pty Ltd. October 10, 2001.
3.Buspar (buspirone hydrochloride) UK summary of product characteristics. Bristol-Myers Squibb Pharmaceuticals Limited August 6, 2002.
4.BuSpar (buspirone hydrochloride) US prescribing information. Bristol Myers Squibb Company September, 2007.