Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Erythromycin may slow down how quickly your liver processes your migraine medicine.
What might happen:
The amount of almotriptan in your body may increase and cause unwanted side effects such as high blood pressure, a rapid heart beat, chest pain, sweating, nausea, or dizziness.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together of if you have taken erythromycin in the previous week. Your doctor may want to change the dose of your migraine medicine while you are taking your antibiotic. If you notice any side effects of your migraine medicine while you are taking your antibiotic, let your doctor know.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Axert (almotriptan) US prescribing information. Ortho-McNeil Neurologics May, 2009.
2.Fleishaker JC, Herman BD, Carel BJ, Azie NE. Interaction between ketoconazole and almotriptan in healthy volunteers. J Clin Pharmacol 2003 Apr;43(4):423-7.
3.Moore KH, Leese PT, McNeal S, Gray P, O'Quinn S, Bye C, Sale M. The pharmacokinetics of sumatriptan when administered with clarithromycin in healthy volunteers. Clin Ther 2002 Apr;24(4):583-94.