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aspirin-acetaminophen-caffeine oral

Adenosine; Hexobendine; Regadenoson/Xanthine Derivatives

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Xanthine derivatives, including caffeine, prevent adenosine, hexobendine and regadenoson from working.

What might happen:

Your adenosine or hexobendine may not work as well.

What you should do about this interaction:

Adenosine and regadenoson are usually used during surgical procedures or in a hospital. Hexobendine is usually used for heart disease. If you are to have either inpatient or outpatient surgery or tests, are to be admitted to the hospital, or started on hexobendine, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


1.Fredholm BB. On the mechanism of action of theophylline and caffeine. Acta Med Scand 1985;217(2):149-53.
2.Smits P, Schouten J, Thien T. Cardiovascular effects of two xanthines and the relation to adenosine antagonism. Clin Pharmacol Ther 1989 Jun; 45(6):593-9.
3.Lexiscan (regadenoson) US prescribing information. Astellas Pharma US, Inc. September, 2011.
4.Hansing CE, Folts JD, Afonso S, Rowe GG. Systemic and coronary hemodynamic effects of hexobendine and its interaction with adenosine and aminophylline. J Pharmacol Exp Ther 1972 Jun;181(3):498-511.
5.Maxwell DL, Fuller RW, Conradson TB, Dixon CM, Aber V, Hughes JM, Barnes PJ. Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man. Acta Physiol Scand 1987 Nov;131(3):459-65.
6.Taddei S, Pedrinelli R, Salvetti A. Theophylline is an antagonist of adenosine in human forearm arterioles. Am J Hypertens 1991 Mar;4(3 Pt 1):256-9.
7.Minton NA, Henry JA. Pharmacodynamic interactions between infused adenosine and oral theophylline. Hum Exp Toxicol 1991 Nov;10(6):411-8.
8.Smits P, Boekema P, De Abreu R, Thien T, van 't Laar A. Evidence for an antagonism between caffeine and adenosine in the human cardiovascular system. J Cardiovasc Pharmacol 1987 Aug;10(2):136-43.
9.Smits P, Schouten J, Thien T. Respiratory stimulant effects of adenosine in man after caffeine and enprofylline. Br J Clin Pharmacol 1987 Dec; 24(6):816-9.
10.Adenoscan (adenosine) US prescribing information. Astellas Pharma US, Inc. February, 2011.

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