Selected Beta-Blockers/Orange Juice
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Medical warning:
Important. Possible changes in your diet, medicine, or dosage should be discussed with your doctor or pharmacist.
How the interaction occurs:
It is unknown how this interaction occurs.
What might happen:
The amount of atenolol or celiprolol that your body absorbs may decrease and it may not work as well.
What you should do about this interaction:
If possible, avoid consuming orange juice while taking atenolol or celiprolol. If you do consume orange juice, wait several hours after taking your atenolol or celiprolol before drinking orange juice and do not take your atenolol or celiprolol with orange juice.Contact your healthcare professional (e.g., doctor or pharmacist) for information.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.
References:
1.Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004 Mar;75(3):184-90.
2.Lilja JJ, Raaska K, Neuvonen PJ. Effects of orange juice on the pharmacokinetics of atenolol. Eur J Clin Pharmacol 2005 Jul; 61(5-6):337-40.
