Pimozide/Grapefruit Juice Interaction
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.
How the interaction occurs:
When grapefruit or grapefruit juice is taken with pimozide, it may increase the amount of this medicine absorbed into your bloodstream.
What might happen:
The level of this medicine in your blood may increase. This may increase your risk of developing a serious kind of irregular heartbeat (arrhythmia).
What you should do about this interaction:
While you are taking this medicine, do not eat grapefruit or drink grapefruit juice at any time. You may choose an alternative citrus beverage (such as orange juice). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with doctor the effects of grapefruit on the blood levels of this medicine.Tell your doctor immediately if you develop an unusually slow, rapid, or irregular heartbeat, or if dizziness/fainting occurs. Contact your healthcare professional for more information.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.
1.Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol 1998 Aug;46(2):101-10.
2.Orap (pimozide) US prescribing information. Gate Pharmaceuticals August, 2011.