Quetiapine/Selected Azole Antifungals
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Azole antifungals may slow down how quickly your liver processes quetiapine.
What might happen:
The amount of quetiapine in your blood may increase and cause side effects such as an unusually fast or slow heartbeat, drowsiness, stomach pain or upset, fever, sore throat, muscle stiffness, vision changes, confusion, sweating, uncontrolled muscle movements, or weakness.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and if you notice an increase in any side effects. Your doctor may want to change the dose of your quetiapine while you are taking your antifungal medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Seroquel (quetiapine fumarate) US prescribing information. AstraZeneca Pharmaceuticals LP July, 2011.
2.Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB. Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. Br J Clin Pharmacol 2006 Jan;61(1):58-69.
