Ketoconazole/Sucralfate
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Sucralfate decreases the amount of ketoconazole that your body absorbs.
What might happen:
The levels of ketoconazole in your blood may decrease and the medicine may not work as well.
What you should do about this interaction:
You should separate the times that you take your ketoconazole and sucralfate by at least two hours.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Carver PL, Berardi RR, Knapp MJ, Rider JM, Kauffman CA, Bradley SF, Atassi M. In vivo interaction of ketoconazole and sucralfate in healthy volunteers. Antimicrob Agents Chemother 1994 Feb;38(2):326-9.
2.Hoeschele JD, Roy AK, Pecoraro VL, Carver PL. In vitro analysis of the interaction between sucralfate and ketoconazole. Antimicrob Agents Chemother 1994 Feb;38(2):319-25.
3.Piscitelli SC, Goss TF, Wilton JH, D'Andrea DT, Goldstein H, Schentag JJ. Effects of ranitidine and sucralfate on ketoconazole bioavailability. Antimicrob Agents Chemother 1991 Sep;35(9):1765-71.
