Tacrine/Cimetidine
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, cimetidine may prevent your body from processing tacrine properly.
What might happen:
Your blood levels of tacrine may increase and cause toxic effects.
What you should do about this interaction:
If you experience dizziness, unsteadiness, clumsiness, nausea, vomiting, diarrhea, or loss of appetite, contact your doctor. It may be necessary to adjust the dose of your medicine or change you to a different medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Cognex (tacrine) US prescribing information. Parke-Davis July, 1996.
2.Brunton LL. Agents for control of gastric acidity and treatment of peptic ulcers. In Gilman AG, Rall TW, Nies AS, Taylor P, editors: Goodman and Gilman's The Phamacological Basis of Therapeutics. 8th edition. Elmsford, New York: Pergamon Press, Inc. 1990.
