Enzalutamide/Strong CYP2C8 Inhibitors
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may slow down your body's metabolism of enzalutamide.
What might happen:
The amount of enzalutamide in your blood may increase and cause more side effects than expected.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any seizures; cold or flu-like symptoms; swelling the hands, arms, legs, or feet; weakness; pink or red urine; or hallucinations.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Xtandi (enzalutamide) US prescribing information. Astellas Pharma US, Inc. August, 2012.