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Coumadin intravenous

Ketorolac/Anticoagulants

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Ketorolac has blood thinning effects and may increase the effects of your blood thinner.

What might happen:

The effect of your blood thinner may increase.You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. This interaction is most likely to occur when starting, stopping or changing the dose of your ketorolac. If your doctor prescribes these two medicines together, you may need to have your bleeding times checked more often. It may be necessary to adjust the dose of your blood thinner. This dose adjustment will be more complicated if you use your ketorolac only when needed and not every day.If you experience bruising or bleeding, contact your doctor. Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.

References:

1.Toradol (ketorolac trometamol) Australian prescribing information. Roche Products Pty Ltd. December 17, 2002.
2.Toradol (ketorolac trometamol) UK summary of product characteristics. Roche Products Limited September 22, 2003.
3.Toradol (ketorolac tromethamine) US prescribing information. Roche Pharmaceuticals March, 2013.

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