Sirolimus/Selected Azole Antifungals (mono deleted 10/24/2013)
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
It is not known exactly how this interaction occurs. Azole antifungals may may increase how quickly your body takes in sirolimus and how much sirolimus your body takes in.
What might happen:
When sirolimus is taken with an azole antifungal, your blood levels of sirolimus may increase. This could be harmful to your kidneys.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.
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