Sirolimus/Selected Azole Antifungals
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
It is not known exactly how this interaction occurs. Azole antifungals may may increase how quickly your body takes in sirolimus and how much sirolimus your body takes in.
What might happen:
When sirolimus is taken with an azole antifungal, your blood levels of sirolimus may increase. This could be harmful to your kidneys.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.
References:
1.Rapamune (sirolimus) US prescribing information. Wyeth Pharmaceuticals March, 2013.
2.Sadaba B, Campanero MA, Quetglas EG, Azanza JR. Clinical relevance of sirolimus drug interactions in transplant patients. Transplant Proc 2004 Dec;36(10):3226-8.
3.Said A, Garnick JJ, Dieterle N, Peres E, Abidi MH, Ibrahim RB. Sirolimus-itraconazole interaction in a hematopoietic stem cell transplant recipient. Pharmacotherapy 2006 Feb;26(2):289-95.
4.Thomas PP, Manivannan J, John GT, Jacob CK. Sirolimus and ketoconazole co-prescription in renal transplant recipients. Transplantation 2004 Feb 15;77(3):474-5.
