Azathioprine; Mercaptopurine/Sulfamethoxazole-Trimethoprim
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines can affect your bone marrow's ability to make new blood cells.
What might happen:
The amount of some types of blood cells in your blood may decrease. This may result in infection or bleeding.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you develop any signs of infection or unusual bleeding or bruising.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Bradley PP, Warden GD, Maxwell JG, Rothstein G. Neutropenia and thrombocytopenia in renal allograft recipients treated with trimethoprim-sulfamethoxazole. Ann Intern Med 1980 Oct;93(4):560-2.
2.Imuran (azathioprine) US prescribing information. Prometheus Laboratories Inc. May, 2011.
3.Hulme B, Reeves DS. Leucopenia associated with trimethoprim-sulphamethoxazole after renal transplantation. Br Med J 1971 Sep 11;3(5775):610-2.
4.Hall CL. Co-trimoxazole and azathioprine: a safe combination. Br Med J 1974 Oct 5;4(5935):15-6.
