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Danocrine oral

Cyclosporine/Selected Androgens

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process cyclosporine properly.

What might happen:

Your blood levels of cyclosporine may increase and cause toxic effects to your liver or kidneys.

What you should do about this interaction:

If you experience yellowing of the skin or eyes, dark urine or pale stools, change in amount of urine, or unusual fatigue, contact your doctor. The dose of your medicines may need adjusting or one may need to be stopped.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of the drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Ross WB, Roberts D, Griffin PJ, Salaman JR. Cyclosporin interaction with danazol and norethisterone. Lancet 1986 Feb 8;1(8476):330.
2.Blatt J, Howrie D, Orlando S, Burckart G. Interaction between cyclosporine and danazol in a pediatric patient. J Pediatr Hematol Oncol 1996 Feb; 18(1):95.
3.Koneru B, Hartner C, Iwatsuki S, Starzl TE. Effect of danazol on cyclosporine pharmacokinetics. Transplantation 1988 May;45(5):1001.
4.Passfall J, Schuller I, Keller F. Pharmacokinetics of cyclosporin during administration of danazol. Nephrol Dial Transplant 1994;9(12):1807-8.
5.Moller BB, Ekelund B. Toxicity of cyclosporine during treatment with androgens. N Engl J Med 1985 Nov 28;313(22):1416.
6.Goffin E, Pirson Y, Geubel A, van Ypersele de Strihou C. Cyclosporine-methyltestosterone interaction. Nephron 1991;59(1):174-5.

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