Carbamazepine/Danazol
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process carbamazepine properly.
What might happen:
The toxic effects of your carbamazepine may increase.
What you should do about this interaction:
If you experience bloating or swelling of the ankles, fainting or dizziness, headache, weakness, fatigue, irregular heartbeat, difficulty speaking, double vision, stomach pain, changes in the frequency of bowel movements, persistent sore throat or fever, joint pain or leg cramps, fever, yellowing of the skin, or dark urine, contact your doctor. It may be necessary to monitor your blood levels of carbamazepine. Your doctor may want to adjust the dose of your medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Kramer G, Theisohn M, von Unruh GE, Eichelbaum M. Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique. Ther Drug Monit 1986;8(4):387-92.
2.Zielinski JJ, Lichten EM, Haidukewych D. Clinically significant danazol-carbamazepine interaction. Ther Drug Monit 1987;9(1):24-7.
3.Anonymous. Danazol-carbamazepine interaction. Int Pharm J 1988;2(1):4-5.
4.Hayden M, Buchanan N. Danazol-carbamazepine interaction. Med J Aust 1991 Dec 2-16;155(11-12):851.
