Dofetilide/Class I and Class III Antiarrhythmics
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When dofetilide is taken with certain antiarrhythmics, the effects on your heart may increase.
What might happen:
When taken together, the effects of these medicines on your heart may increase, possibly causing life-threatening effects.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Tikosyn (dofetilide) US prescribing information. Pfizer Inc. February, 2011.
2.Rythmol (propafenone hydrochloride) US prescribing information. Abbott Laboratories March, 2013.