Selected Protease Inhibitors/Rifapentine
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Rifapentine may speed up how quickly your liver processes your protease inhibitor.
What might happen:
The amount of protease inhibitor in your blood may decrease and it may not work as well. Your HIV might become resistant to your protease inhibitor.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have taken rifapentine in the previous two weeks. Your doctor may want to change your medicine or check the amount of protease inhibitor in your blood.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Priftin (rifapentine) US prescribing information. Sanofi-Aventis U.S. LLC July, 2010.
2.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.