Selected Protease Inhibitors/Didanosine
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When indinavir and didanosine are taken at the same time, your body absorbs less indinavir.When darunavir/ritonavir, lopinavir/ritonavir capsules or solution, or plain ritonavir and didanosine are taken at the same time, your body absorbs less didanosine.
What might happen:
If you take indinavir at the same time as your didanosine, the levels of indinavir in your blood may decrease, making it less effective.If you take darunavir/ritonavir, lopinavir/ritonavir capsules or solution, or plain ritonavir at at the same time as your didanosine, the levels of didanosine in your blood may decrease, making it less effective.
What you should do about this interaction:
You should not take didanosine at the same time that you take your darunavir/ritonavir, indinavir, lopinavir/ritonavir capsules or solution, or ritonavir.You should separate the times that you take your indinavir and didanosine by at least one hour.Take your didanosine at least one hour before or two hours after your darunavir/ritonavir, or lopinavir/ritonavir capsules or solution. Lopinavir/ritonavir tablets may be taken at the same time as didanosine.You should separate the times that you take your plain ritonavir and didanosine by at least two and one-half hours.If you have been taking these medicines at the same time, let your healthcare professionals (e.g. doctor or pharmacist) know. Your doctor may want to run some blood tests to see if your medicines are working properly.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Videx (didanosine) US prescribing information. Bristol-Myers Squibb Company November, 2011.
2.Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. February, 2011.
3.Prezista (darunavir) US prescribing information. Tibotec Inc. February, 2013.
4.Kaletra (lopinavir/ritonavir capsules) US prescribing information. Abbott Laboratories January, 2013.
5.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2012.
6.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories January, 2013.
