Pioglitazone; Rosiglitazone/Rifampin
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, rifampin may cause your body to process your diabetes medicine more quickly.
What might happen:
A decrease in the beneficial effects of your diabetes medicine may occur.
What you should do about this interaction:
If you experience pale skin, blurred vision, loss of consciousness, increased thirst, increased urination, blurred vision, fatigue, or fast, deep breathing, contact your doctor. It may be necessary for you to check your blood sugar levels more often. Your doctor may need to adjust the dose of your diabetes medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Jaakkola T, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ. Effect of rifampicin on the pharmacokinetics of pioglitazone. Br J Clin Pharmacol 2006 Jan;61(1):70-8.
2.Actos (pioglitazone hydrochloride) US prescribing information. Takeda Pharmaceuticals Inc. May, 2012.
3.Niemi M, Backman JT, Neuvonen PJ. Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone. Clin Pharmacol Ther 2004 Sep;76(3):239-49.
4.Park JY, Kim KA, Kang MH, Kim SL, Shin JG. Effect of rifampin on the pharmacokinetics of rosiglitazone in healthy subjects. Clin Pharmacol Ther 2004 Mar;75(3):157-62.
