Skip to content
My WebMD Sign In, Sign Up

Coreg CR oral

Clonidine/Beta-Blockers

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

These two medicines are taken together to help lower your blood pressure. In some people, they may increase blood pressure. If you stop taking clonidine and continue taking your beta-blocker, or if you stop taking them both at the same time, your blood pressure may also increase.

What might happen:

Your blood pressure may increase to a dangerous level, causing headache, nausea, vomiting, flushing, confusion, tremor, irritability with unrest, or a fast or irregular heartbeat.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. You may need to check your blood pressure more often when starting or stopping these medicines. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Follow closely any instructions that your doctor gives you about stopping these medicines.

References:

1.Bailey RR, Neale TJ. Rapid clonidine withdrawal with blood pressure overshoot exaggerated by beta-blockade. Br Med J 1976 Apr 17; 1(6015):942-3.
2.Strauss FG, Franklin SS, Lewin AJ, Maxwell MH. Withdrawal of antihypertensive therapy. Hypertensive crisis in renovascular hypertension. JAMA 1977 Oct 17;238(16):1734-6.
3.Vernon C, Sakula A. Fatal rebound hypertension after abrupt withdrawal of clonidine and propranolol. Br J Clin Pract 1979 Apr;33(4):112, 121.
4.Bruce DL, Croley TF, Lee JS. Preoperative clonidine withdrawal syndrome. Anesthesiology 1979 Jul;51(1):90-2.
5.Warren SE, Ebert E, Swerdlin AH, Steinberg SM, Stone R. Clonidine and propranolol paradoxical hypertension. Arch Intern Med 1979 Feb;139(2):253.
6.Lilja M, Jounela AJ, Juustila H, Mattila MJ. Interaction of clonidine and beta-blockers. Acta Med Scand 1980;207(3):173-6.
7.Garvey HL, Woodhouse BL. Reversal of clonidine-induced hypotension by beta-adrenoceptor blocking drugs. Eur J Pharmacol 1980 Jul 11;65(1):55-62.
8.Rosenthal T, Rabinowitz B, Boichis H, Elazar E, Brauner A, Neufeld HN. Use of labetalol in hypertensive patients during discontinuation of clonidine therapy. Eur J Clin Pharmacol 1981;20(4):237-40.
9.Cummings DM, Vlasses PH. Antihypertensive drug withdrawal syndrome. Drug Intell Clin Pharm 1982 Nov;16(11):817-22.
10.Lilja M. Interaction of clonidine and labetalol in hypertension. Acta Med Scand 1983;214(2):119-24.
11.Jounela AJ, Lilja M. Interactions between beta-blockers and clonidine. Ann Clin Res 1984;16(4):181-2.

See 66 Reviews for this Drug. - OR -

Review this Treatment

Find a Drug:

by name or medical condition or shape/color (Pill Identifier)

(for example: aspirin)

(for example: diabetes)

Report Problems to the Food and Drug Administration
 
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Health Solutions From Our Sponsors

Ask the pharmacist

Questions about medications? Get expert answers by video or live chat about allergies, pregnancy, sleep, and more.
See the Ask the Pharmacist event schedule.

Ask a Question

Popular Slideshows & Tools on WebMD

tea
What you should eat.
Woman sitting in front of UV lights
Is yours working?
woman using breath spray
What's causing yours?
colon xray
Get the facts.
MS Overview
Recognizing symptoms.
bowl of yogurt with heart shape
Eat for a healthy heart.
woman doing pushups
To help you get fit.
Colored x-ray of tooth decay
Know what to look for.
Woman sitting with child
Do you know the symptoms?
fruit drinks
Foods that can help you focus.
Sad dog and guacamole
Don't feed this to your dog.
Thyroid exam
See how much you know.

Women's Health Newsletter

Find out what women really need.

WebMD the app

Get trusted health information. Whenever. Wherever... with your iPhone, iPad or Android.

Find Out More

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.