Selected Antineoplastic Systemic Enzyme Inhibitors/ Grapefruit or Seville Oranges
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.
How the interaction occurs:
Grapefruit and Seville oranges may slow down how quickly your body processes your cancer medicine.
What might happen:
The amount of your cancer medicine in your blood may increase and cause more side effects than normal.
What you should do about this interaction:
While you are taking this medicine, you should not eat grapefruit or drink grapefruit juice or eat Seville oranges (often found in marmalades) at any time. You may choose an alternative citrus (such as non-Seville oranges). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with your doctor the effects of grapefruit on the blood levels of this medicine.Contact your healthcare professional (e.g., doctor or pharmacist) for more information.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.
1.Inlyta (axitinib) US prescribing information. Pfizer Inc. January, 2012.
2.Bosulif (bosutinib) US prescribing information. Pfizer Inc. August, 2012.
3.Cometriq (cabozantinib) US prescribing information. Exelixix, Inc. November 29, 2012.
4.Xalkori (crizotinib) US prescribing information. Pfizer Inc. November, 2013.
5.Tafinlar (dabrafenib) US prescribing information. GlaxoSmithKline May, 2013.
6.Sprycel (dasatinib) US prescribing information. Bristol-Myers Squibb Company June, 2013.
7.Tarceva (erlotinib) US prescribing information. Genentech, Inc. April, 2012.
8.Imbruvica (ibrutinib) US prescribing information. Janssen Biotech, Inc. November, 2013.
9.Tykerb (lapatinib) US prescribing information. GlaxoSmithKline January 29, 2010.
10.Tasigna (nilotinib) US prescribing information. Novartis Pharmaceuticals Corporation June, 2013.
11.Votrient (pazopanib) US prescribing information. GlaxoSmithKline November, 2013.
12.Sutent (sunitinib malate) US prescribing information. Pfizer Labs. January, 2006.